A microfluidic device for monitoring biomolecular interactions in complex solutions (even colloids!). 

There is a world of difference between a protein in a buffered dilute solution and the inside of cell—particularly when thinking about how proteins interact with their surroundings. This is a constant worry for those of us that often work on protein in isolation. To address this we have set out to design a device that monitors interactions in real time and in complex solutions, such as the contents of a cell. This is the Holy Grail for those interesting in characterizing biomolecular interactions and we have already developed the prototype and done the first proof-of-principle experiments with green fluorescent protein.