Publications

immun39_3.c1.indd
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bic1621-16-cover.indd
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Covers

You can get a full list from Pubmed here.
ORCID is 0000-0002-5506-4939.
Our Google Scholar page his here.

(2003-2017)

2017

  1.  I. Kavianinia, S. H. Yang, H. Kaur, P. W. R. Harris, R. C. J. Dobson, A. J. Fairbanks, and M. A. Brimble (2017) “Synthesis and incorporation of an advanced lipid peroxidation end-product building block into collagen mimetic peptides.” Chem Comm., in press
  1.  V. V. Rogov, A. Stolz, A. C. Ravicahandran, D. O. Rios-Szwed, H. Suzuki, A. Kniss, F. Löhr, S. Wakatsuki, V. Dötsch, I. Dikic*, R. C. J. Dobson* and D. G. McEwan* (2017) “Structural and Functional analysis of the GABARAP Interaction Motif (GIM).” EMBO R., in press (http://embor.embopress.org/content/early/2017/06/27/embr.201643587)
    * corresponding author
  1. S. A. J. Watkin, T. M. Ryan, A. G. Miller, V. M. Nock, F. G. Pearce and R. C. J. Dobson (2017) “Microfluidics for Small-Angle X-ray Scattering.” in X-ray Scattering, (A. E. Ares, eds.), Rijeka: InTech Chapter 4, pp. 89-104.  Bookchapter.
  1. A. O. Hudson, M. A. Savka, F. G. Pearce and R. C. J. Dobson (2017) “Lysine biosynthesis in microorganisms.” in Handbook of Microbial Metabolism of Amino Acids,Chapter 4, pp. 49-69.  Bookchapter.
  1. F. G. Pearce, A. O. Hudson, K. Loomes, R. C. J. Dobson (2017) “Dihydrodipicolinate synthase: Structure, dynamics, function, and evolution.” Subcellular Biochemistry,  vol. 83, pp. 271-289.

2016

  1. R. A. North, A. J. A. Watson, F. G. Pearce, A. C. Muscroft-Taylor, R. Friemann, A. J. Fairbanks and R. C. J. Dobson (2016) “Structure and inhibition of N-acetylneuraminate lyase from methicillin-resistant Staphylococcus aureus.” FEBS Letters, vol. 590, no. 23, pp. 4414-28. Link
  1. J. M. Crowther, G. B. Jameson, A. J. Hodgkinson and R. C. J. Dobson (2016) “Structure, oligomerisation and interactions of β-lactoglobulin.” in Milk Proteins – from structure to biological properties and health aspects, Edited by Isabel Gigli, ISBN 978-953-51-4584-4, pp. 33-50.  Bookchapter.
  1. A. R. Cala, M. T. Nadeau, B. L. Staker, A. W. Weatherhead, R. C. J. Dobson, J. Abendroth, P. J. Myler and A. O. Hudson (2016) “The crystal structure of dihydrodipicolinate reductase at 2.3 Å resolution from the human pathogenic bacterium Bartonella henselae str. Houston-1.” Acta Crystallogr F Struct Biol Commun., vol. 72, no. 12, pp. 885-91.
  1. S. U. Umu, A. M. Poole, R. C. J. Dobson and P. P. Gardner (2016) “Avoidance of stochastic RNA interactions can be harnessed to control protein expression levels in bacteria and archaea.” eLife, vol. 5, pp. e13479. Link
  1. J. Lee, N. Joshi, R. Pasini, R. C. J. Dobson, J. A. Allison and T. Leustek (2016) “Inhibition of Arabidopsis growth by the allelopathic compound azetadine 2-carboxylate is due to the low amino acid specificity of cytosolic prolyl-tRNA synthetase.” Plant J., vol. 88, no. 2, pp. 236-46.
  1. K. Chen, R. C. J. Dobson, I. S. Lucet, S. N. Young, F. G. Pearce, M. E. Blewitt and J. M. Murphy (2016) “The epigenetic regulator Smchd1 contains a functional GHKL-type ATPase domain.” Biochem J., vol 473, no. 12, pp. 1733-44. Link
  1. K. F. Naqvi, D. Patin, M. S. Wheatley, M. A. Savka, R. C. J. Dobson, H. M. Gan, H. Barreteau, D. Blanot, D. Mengin-Lecreul and A. O. Hudson, (2016) “Identification and partial characterization of a novel UDP-N-acetylenolpyruvoylglucosamine reductase/UDP-N-acetylmuramate:L-alanine ligase fusion enzyme from Verrucomicrobium spinosum DSM 4136T.” Front Microbiol., vol. 7, article 362. Link
  1. bic1621-16-cover.inddS. Poen, Y. Nakatani, H. K. Opel-Reading, M. Lassé, R. C. J. Dobson and K. L. Krause, (2016) “Exploring the structure of glutamate racemase from Mycobacterium tuberculosis as a template for anti-mycobacterial drug discovery.” Biochem J., vol. 473, no. 9, pp. 1267-80. Link
  1. K. A. Donovan, S. Zhu, P. Liuni, F. Peng, S. A. Kessans, D. J. Wilson and R. C. J. Dobson, (2016) “Conformational dynamics and allostery in pyruvate kinase.” J Biol Chem., vol. 291, no. 17, pp. 9244-9256. Link
  1. Screen Shot 2016-05-14 at 7.43.15 PMK. A. Donovan, S. C. Atkinson, S. A. Kessans, F. Peng, T. F. Cooper, M. D. W. Griffin, G. B. Jameson and R. C. J. Dobson (2016) “Grappling with anisotropic data, pseudo-merohedral twinning and pseudo-translational non-crystallographic symmetry: A case study involving pyruvate kinase.” Acta Crystallogr D Biol Crystallogr., vol. 72, no. 4, pp. 512-9. Link
  1. K. F. Naqvi, B. L. Staker, R. C. J. Dobson, D. Serbzhinskiy, B. Sankaran, P. J. Myler and A. O. Hudson (2016) “Cloning, expression, purification, crystallization and X-ray diffraction analysis of dihydrodipicolinate synthase from the human pathogenic bacterium Bartonella henselae strain Houston-1 at 2.1 Å resolution.” Acta Crystallogr F Struct Biol Commun., vol. 72, no. 1, pp. 2-9. Link
  1. D. J. Klionsky, et al. (2016) “Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).” Autophagy, vol. 12, no. 1, pp. 1-222. Link

2015

  1. K. Chen, J. Hu, D. L. Moore, R. Liu, S. A. Kessans, K. Breslin, I. S. Lucet, A. Keniry, H. S. Leong, C. L. Parish, D. J. Hilton, R. J. L. F. Lemmers, S. M. van der Maarel, P. E. Czabotar, R. C. J. Dobson, M. E. Ritchie, G. F. Kay, J. M. Murphy and M. E. Blewitt (2015) “Genome-wide binding and mechanistic analyses of Smchd1-mediated epigenetic regulation.” Proc Natl Acad Sci U.S.A., vol. 112, no. 27, pp. E3535–44. Link

2014

  1. Screen Shot 2015-10-11 at 10.27.03 AM
    Structure of goat β-lactoglobulin.

    J. M. Crowther, M. Lassé, H. Suzuki, S. A. Kessans, T. S. Loo, G. E. Norris, A. J. Hodgkinson, G. B. Jameson and R. C. J. Dobson (2014) “Ultra-high resolution crystal structure of recombinant caprine β-lactoglobulin.” FEBS Lett., vol. 588, no. 21, pp. 3816–3822. Link

  1. A. J. Triassi, M. S. Wheatley, M. A. Savka, H. M. Gan, R. C. J. Dobson and A. O. Hudson (2014) “L,L-diaminopimelate aminotransferase (DapL): a putative target for the development of narrow-spectrum antibacterial compounds.” Front Microbial., vol. 5, p. 509, 2014. Link
  1. S. M. K. McKinnie, E. M. Rodriguez-Lopez, J. C. Vederas, J. M. Crowther, H. Suzuki, R. C. J. Dobson, T. Leustek, A. J. Triassi, M. S. Wheatley and A. O. Hudson (2014) “Differential response of orthologous L,L-diaminopimelate aminotransferases (DapL) to enzyme inhibitory antibiotic lead compounds.” Bioorg Med Chem., vol. 22, no. 1, pp. 523–530. Link
  1. stfode 22_1.c2.inddH. Suzuki*, K. Tabata, E. Morita, M. Kawasaki, R. Kato, R. C. J. Dobson*, T. Yoshimori and S. Wakatsuki (2014) “Structural basis of the autophagy-related LC3/Atg13 LIR complex: recognition and interaction mechanism.” Structure, vol. 22, no. 1, pp. 47–58. Link
    * corresponding author
    .
    This work was the subject of an invited commentary: “A Small Switch Has a Large Effect on Autophagy” Winfried Weissenhorn, Marie-Odile Fauvarque. Link
  1. A. R. Nazmi, L. R. Schofield, R. C. J. Dobson, G. B. Jameson and E. J. Parker (2014) “Destabilization of the homotetrameric assembly of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from the hyperthermophile Pyrococcus furiosus enhances enzymatic activity.” J Mol Biol., vol. 426, no. 3, pp. 656–673. Link
  1. R. A. North, S. Seizova, A. Stampfli, S. A. Kessans, H. Suzuki, M. D. W. Griffin, M. Kvansakul and R. C. J. Dobson (2014) “Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of N-acetylmannosamine kinase from methicillin-resistant Staphylococcus aureus.” Acta Crystallogr F Struct Biol Commun., vol. 70, no. 5, pp. 643–649. Link
  1. M. R. Oliver, J. M. Crowther, M. M. Leeman, S. A. Kessans, R. A. North, K. A. Donovan, M. D. W. Griffin, H. Suzuki, A. O. Hudson, M. Kasanmascheff and R. C. J. Dobson (2014) “The purification, crystallization and preliminary X-ray diffraction analysis of two isoforms of meso-diaminopimelate decarboxylase from Arabidopsis thaliana.” Acta Crystallogr F Struct Biol Commun., vol. 70, no. 5, pp. 663–668. Link
  1. R. A. North, S. A. Kessans, M. D. W. Griffin, A. J. A. Watson, A. J. Fairbanks and R. C. J. Dobson (2014) “Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of N-acetylmannosamine-6-phosphate 2-epimerase from methicillin-resistant Staphylococcus aureus.” Acta Crystallogr F Struct Biol Commun., vol. 70, no. 5, pp. 650–655. Link
  1. S. C. Atkinson, L. Hor, C. Dogovski, R. C. J. Dobson and M. A. Perugini (2014) “Identification of the bona fide DHDPS from a common plant pathogen.” Proteins, vol. 82, no. 9, pp. 1869–1883. Link
  1. T. L. Putoczki, R. C. J. Dobson and M. D. W. Griffin (2014) “The structure of human interleukin-11 reveals receptor-binding site features and structural differences from interleukin-6.” Acta Crystallogr D Biol Crystallogr., vol. 70, no. 9, pp. 2277–2285. Link

    Our structure of IL-11 demonstrates that it really is different to IL-6
  1. J. M. Hildebrand, M. C. Tanzer, I. S. Lucet, S. N. Young, S. K. Spall, P. Sharma, C. Pierotti, J.-M. Garnier, R. C. J. Dobson, A. I. Webb, A. Tripaydonis, J. J. Babon, M. D. Mulcair, M. J. Scanlon, W. S. Alexander, A. F. Wilks, P. E. Czabotar, G. Lessene, J. M. Murphy and J. Silke (2014) “Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death.” Proc Natl Acad Sci U.S.A., vol. 111, no. 42, pp. 15072–15077. Link

2013

  1. A. Sikorski, G. R. Argüello-Astorga, A. Dayaram, R. C. J. Dobson and A. Varsani (2013) “Discovery of a novel circular single-stranded DNA virus from porcine faeces.” Arch Virol., vol. 158, no. 1, pp. 283–289. Link
  1. S. C. Atkinson, C. Dogovski, M. T. Downton, P. E. Czabotar, R. C. J. Dobson, J. A. Gerrard, J. Wagner and M. A. Peruguini (2013) “Structural, kinetic and computational investigation of Vitis vinifera DHDPS reveals new insight into the mechanism of lysine-mediated allosteric inhibition.” Plant Mol Biol., vol. 81, no. 4, pp. 431–446. Link
  1. R. A. North, S. A. Kessans, S. C. Atkinson, H. Suzuki, A. J. A. Watson, B. R. Burgess, L. M. Angley, A. O. Hudson, A. Varsani, M. D. W. Griffin, A. J. Fairbanks, and R. C. J. Dobson, (2013) “Cloning, expression, purification, crystallization and preliminary X-ray diffraction studies of N-acetylneuraminate lyase from methicillin-resistant Staphylococcus aureus.” Acta Crystallogr Sect F Struct Biol Cryst Commun., vol. 69, no. 3, pp. 306–312. Link
  1. P. J. Cross, T. M. Allison, R. C. J. Dobson, G. B. Jameson and E. J. Parker (2013) “Engineering allosteric control to an unregulated enzyme by transfer of a regulatory domain.” Proc Natl Acad Sci U.S.A., vol. 110, no. 6, pp. 2111–2116. Link
  1. L. Hor, R. C. J. Dobson, M. T. Downton, J. Wagner, C. A. Hutton and M. A. Perugini (2013) “Dimerization of bacterial diaminopimelate epimerase is essential for catalysis.” J Biol Chem., vol. 288, no. 13, pp. 9238–9248. Link
  1. S. E. McGroty, D. T. Pattaniyil, D. Patin, D. Blanot, A. C. Ravichandran, H. Suzuki, R. C. J. Dobson, M. A. Savka and A. O. Hudson (2013) “Biochemical characterization of UDP-N-acetylmuramoyl-L-alanyl-D-glutamate: meso-2,6-diaminopimelate ligase (MurE) from Verrucomicrobium spinosum DSM 4136T.” PLoS ONE, vol. 8, no. 6, pp. e66458–9. Link

    Screen Shot 2015-10-11 at 10.47.26 AM
    Structure of diaminopimelate epimerise (dapF)
  1. M. D. W. Griffin, J. M. Billakanti, A. Wason, S. Keller, H. D. T. Mertens, S. C. Atkinson, R. C. J. Dobson, M. A. Perugini, J. A. Gerrard and F. G. Pearce (2013) “Characterisation of the first enzymes committed to lysine biosynthesis in Arabidopsis thaliana.” PLoS ONE, vol. 7, no. 7, p. e40318. Link
  1. V. R. Nachar, F. C. Savka, S. E. McGroty, K. A. Donovan, R. A. North, R. C. J. Dobson, L. J. Buckley and A. O. Hudson (2013) “Genomic and biochemical analysis of the diaminopimelate and lysine biosynthesis pathway in Verrucomicrobium spinosum: Identification and partial characterization of L,L-diaminopimelate aminotransferase and UDP-N-Acetylmuramoylalanyl-D-glutamyl-2,6-meso-diaminopimelate ligase.” Front Microbial., vol. 3, p. 183. Link
  1. A. Dayaram, A. Opong, A. Jäschke, J. Hadfield, M. Baschiera, R. C. J. Dobson, S. K. Offei, D. N. Shepherd, D. P. Martin and A. Varsani (2013) “Molecular characterisation of a novel cassava associated circular ssDNA virus,” Virus Res., vol. 166, no. 1, pp. 130–135. Link
  1. C. F. Reboul, B. T. Porebski, M. D. W. Griffin, R. C. J. Dobson, M. A. Perugini, J. A. Gerrard, and A. M. Buckle, (2013) “Structural and dynamic requirements for optimal activity of the essential bacterial enzyme dihydrodipicolinate synthase.” PLoS Compute Biol., vol. 8, no. 6, pp. e1002537–12. Link
  1. S. C. Atkinson, C. Dogovski, M. T. Downton, F. G. Pearce, C. F. Reboul, A. M. Buckle, J. A. Gerrard, R. C. J. Dobson, J. Wagner and M. A. Perugini (2013) “Crystal, Solution and in silica structural studies of dihydrodipicolinate synthase from the common grapevine.” PLoS ONE, vol. 7, no. 6, pp. e38318–9. Link
  1. bpj103_2.c1.inddD. Mercadante, L. D. Melton, G. E. Norris, T. S. Loo, M. A. K. Williams, R. C. J. Dobson and G. B. Jameson (2013) “Bovine β-lactoglobulin is dimeric under imitative physiological conditions: dissociation equilibrium and rate constants over the pH range of 2.5-7.5.” Biophys J., vol. 103, no. 2, pp. 303–312. Link
  1. B. A. Boughton, R. C. J. Dobson and C. A. Hutton (2013) “The crystal structure of dihydrodipicolinate synthase from Escherichia coli with bound pyruvate and succinic acid semialdehyde: unambiguous resolution of the stereochemistry of the condensation product.” Proteins, vol. 80, no. 8, pp. 2117–2122. Link
  1. S. C. Atkinson, C. Dogovski, R. C. J. Dobson and M. A. Perugini (2013) “Cloning, expression, purification and crystallization of dihydrodipicolinate synthase from Agrobacterium tumefaciens.” Acta Crystallogr Sect F Struct Biol Cryst Commun., vol. 68, no. 9, pp. 1040–1047. Link

2011

  1. A. O. Hudson†, I. Girón and R. C. J. Dobson† (2011) “Crystallization and preliminary X-ray diffraction analysis of L,L-diaminopimelate aminotransferase (DapL) from Chlamydomonas reinhardtii.” Acta Crystallogr Sect F Struct Biol Cryst Commun., vol. 67, no. 1, pp. 140–143. Link
    † = Corresponding author
  1. N. A. Veldhuis, M. J. Kuiper, R. C. J. Dobson, R. B. Pearson and J. Camakaris (2011) “In silico modeling of the Menkes copper-translocating P-type ATPase 3rd metal binding domain predicts that phosphorylation regulates copper-binding.” Biometals, vol. 24, no. 3, pp. 477–487. Link
  1. N. J. Gunn, M. A. Gorman, R. C. J. Dobson, M. W. Parker and T. D. Mulhern (2011) “Purification, crystallization, small-angle X-ray scattering and preliminary X-ray diffraction analysis of the SH2 domain of the Csk-homologous kinase.” Acta Crystallogr Sect F Struct Biol Cryst Commun., vol. 67, no. 3, pp. 336–339, Mar. 2011. Link
  1. P. J. Cross, R. C. J. Dobson, M. L. Patchett and E. J. Parker (2011) “Tyrosine latching of a regulatory gate affords allosteric control of aromatic amino acid biosynthesis.” J Biol Chem., vol. 286, no. 12, pp. 10216–10224. Link
  1. R. C. J. Dobson†, I. Girón and A. O. Hudson† (2011) “L,L-Diaminopimelate aminotransferase from Chlamydomonas reinhardtii: A Target for algaecide development.” PLoS ONE, vol. 6, no. 5, pp. e20439–13. Link
    † = Corresponding author
  1. G. Evans, L. Schuldt, M. D. W. Griffin, S. R. A. Devenish, F. Grant Pearce, M. A. Perugini, R. C. J. Dobson, G. B. Jameson, M. S. Weiss and J. A. Gerrard (2011) “A tetrameric structure is not essential for activity in dihydrodipicolinate synthase (DHDPS) from Mycobacterium tuberculosis.” Arch Biochem Biophys., vol. 512, no. 2, pp. 154–159. Link
  1. A. O. Hudson, A. Klartag, C. Gilvarg, R. C. J. Dobson, F. G. Marques and T. Leustek (2011) “Dual diaminopimelate biosynthesis pathways in Bacteroides fragilis and Clostridium thermocellum.” Biochim Biophys Acta, vol. 1814, no. 9, pp. 1162–1168. Link
  1. M. D. W. Griffin, J. M. Billakanti, J. A. Gerrard, R. C. J. Dobson and F. G. Pearce (2011) “Crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase 2 from Arabidopsis thaliana.” Acta Crystallogr Sect F Struct Biol Cryst Commun., vol. 67, no. 11, pp. 1386–1390. Link
  1. F. G. Pearce, R. C. J. Dobson, G. B. Jameson, M. A. Perugini and J. A. Gerrard (2011) “Characterization of monomeric dihydrodipicolinate synthase variant reveals the importance of substrate binding in optimising oligomerization.” BBA – Proteins and Proteomics, vol. 1814, no. 12, pp. 1900–1909. Link
  1. S. C. Atkinson, C. Dogovski, J. Newman, R. C. J. Dobson, and M. A. Perugini, (2011) “Cloning, expression, purification and crystallization of dihydrodipicolinate synthase from the grapevine Vitis vinifera.” Acta Crystallogr Sect F Struct Biol Cryst Commun., vol. 67, no. 12, pp. 1537–1541. Link

2010

  1. S. Dommaraju, M. A. Gorman, C. Dogovski, F. G. Pearce, J. A. Gerrard, R. C. J. Dobson, M. W. Parker and M. A. Perugini (2010) “Cloning, expression and crystallization of dihydrodipicolinate reductase from methicillin-resistant Staphylococcus aureus.” Acta Crystallogr Sect F Struct Biol Cryst Commun., vol. 66, no. 1, pp. 57–60.
  1. L. J. Domigan, S. W. Scally, M. J. Fogg, C. A. Hutton, M. A. Perugini, R. C. J. Dobson, A. C. Muscroft-Taylor, J. A. Gerrard and S. R. A. Devenish (2010) “Characterisation of dihydrodipicolinate synthase (DHDPS) from Bacillus anthracis.” Biochim. Biophys. Acta, vol. 1794, no. 10, pp. 1510–1516. Link
  1. T. Zhu, M. F. Bailey, L. M. Angley, T. F. Cooper and R. C. J. Dobson (2010) “The quaternary structure of pyruvate kinase type 1 from Escherichia coli at low nanomolar concentrations.” Biochimie, vol. 92, no. 1, pp. 116–120. Link
  1. L. Hor&, R. C. J. Dobson&, C. Dogovski, C. A. Hutton and M. A. Perugini (2010) “Crystallization and preliminary X-ray diffraction analysis of diaminopimelate epimerase from Escherichia coli.” Acta Crystallogr Sect F Struct Biol Cryst Commun., vol. 66, no. 1, pp. 37–40. Link
    & = Joint first author
  1. ABB_coverM. D. W. Griffin, R. C. J. Dobson, J. A. Gerrard and M. A. Perugini (2010) “Exploring the dihydrodipicolinate synthase tetramer: How resilient is the dimer–dimer interface?” Arch Biochem Biophys., vol. 494, no. 1, pp. 58–63. Link
  1. J. E. Voss, S. W. Scally, N. L. Taylor, S. C. Atkinson, M. D. W. Griffin, C. A. Hutton, M. W. Parker, M. R. Alderton, J. A. Gerrard, R. C. J. Dobson, C. Dogovski and M. A. Perugini (2010) “Substrate-mediated stabilization of a tetrameric drug target reveals Achilles heel in anthrax.” J Biol Chem., vol. 285, no. 8, pp. 5188–5195. Link
  1. T. P. Soares da Costa, A. C. Muscroft-Taylor, R. C. J. Dobson, S. R. A. Devenish, G. B. Jameson and J. A. Gerrard (2010) “How essential is the ‘essential’ active-site lysine in dihydrodipicolinate synthase?” Biochimie, vol. 92, no. 7, pp. 837–845. Link
  1. J. M. Wubben, C. Dogovski, R. C. J. Dobson, R. Codd, J. A. Gerrard, M. W. Parker and M. A. Perugini (2010) “Cloning, expression, purification and crystallization of dihydrodipicolinate synthase from the psychrophile Shewanella benthica.” Acta Crystallogr Sect F Struct Biol Cryst Commun., vol. 66, no. 11, pp. 1511–1516. Link
  1. A. C. Muscroft-Taylor, R. J. Catchpole, R. C. J. Dobson, F. G. Pearce, M. A. Perugini and J. A. Gerrard (2010) “Disruption of quaternary structure in Escherichia coli dihydrodipicolinate synthase (DHDPS) generates a functional monomer that is no longer inhibited by lysine.” Arch Biochem Biophys., vol. 503, no. 2, pp. 202–206. Link
  1. K.-C. Chan, D. S.-S. Lio, R. C. J. Dobson, B. Jarasrassamee, M. I. Hossain, A. K. Roslee, K. K. Ia, M. A. Perugini and H.-C. Cheng (2010) “Development of the procedures for high-yield expression and rapid purification of active recombinant Csk-homologous kinase (CHK): Comparison of the catalytic activities of CHK and CSK.” Prot Express Purif., vol. 74, no. 2, pp. 139–147. Link

2009

  1. L. J. Domigan, S. W. Scally, M. J. Fogg, C. A. Hutton, M. A. Perugini, R. C. J. Dobson, A. C. Muscroft-Taylor, J. A. Gerrard and S. R. A. Devenish (2009) “Characterisation of dihydrodipicolinate synthase (DHDPS) from Bacillus anthracis.” Biochim Biophys. Acta, vol. 1794, no. 10, pp. 1510–1516. Link
  1. C. Dogovski, S. C. Atkinson, S. R. Dommaraju, R. C. J. Dobson and M. A. Perugini, (2009) “Lysine biosynthesis in bacteria: an unchartered pathway for novel antibiotic design.” in Book Chapter – Encyclopedia of life support systems, vol. 11, pp. 116–136.  Bookchapter.
  1. P. F. James&, C. Dogovski&, R. C. J. Dobson&, M. F. Bailey, K. N. Goldie, J. A. Karas, D. B. Scanlon, R. A. J. O’Hair and M. A. Perugini (2009) “Aromatic residues in the C-terminal helix of human apoC-I mediate phospholipid interactions and particle morphology.” J Lipid Res., vol. 50, no. 7, pp. 1384–1394. Link
    & = Joint first author.
  1. B. B. B. Guo, S. R. A. Devenish, R. C. J. Dobson, A. C. Muscroft-Taylor and J. A. Gerrard (2009) “The C-terminal domain of Escherichia coli dihydrodipicolinate synthase (DHDPS) is essential for maintenance of quaternary structure and efficient catalysis.” Biochem Biophys Res Commun., vol. 380, no. 4, pp. 802–806. Link
  1. S. C. Atkinson&, R. C. J. Dobson&,†, J. M. Newman, M. A. Gorman, C. Dogovski, M. W. Parker and M. A. Perugini (2009) “Crystallization and preliminary X-ray analysis of dihydrodipicolinate synthase from Clostridium botulinum in the presence of its substrate pyruvate.” Acta Crystallogr Sect F Struct Biol Cryst Commun., vol. 65, no. 3, pp. 253–255. Link
    & = Joint first author † = Corresponding author
  1. J. E. Voss, S. W. Scally, N. L. Taylor, C. Dogovski, M. R. Alderton, C. A. Hutton, J. A. Gerrard, M. W. Parker, R. C. J. Dobson† and M. A. Perugini† (2009) “Expression, purification, crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase from Bacillus anthracis in the presence of pyruvate.” Acta Crystallogr Sect F Struct Biol Cryst Commun., vol. 65, no. 2, pp. 188–191. Link
    † = Corresponding author
  1. R. C. J. Dobson†, M. A. Perugini, G. B. Jameson and J. A. Gerrard (2009) “Specificity versus catalytic potency: The role of threonine 44 in Escherichia coli dihydrodipicolinate synthase mediated catalysis.” Biochimie, vol. 91, no. 8, pp. 1036–1044. Link
    † = Corresponding author

2008

  1. B. A. Boughton, M. D. W. Griffin, P. A. O’Donnell, R. C. J. Dobson, M. A. Perugini, J. A. Gerrard and C. A. Hutton (2008) “Irreversible inhibition of dihydrodipicolinate synthase by 4-oxo-heptenedioic acid analogues.” Bioorg Med Chem., vol. 16, no. 23, pp. 9975–9983. Link
  1. B. A. Boughton, R. C. J. Dobson, J. A. Gerrard and C. A. Hutton (2008) “Conformationally constrained diketopimelic acid analogues as inhibitors of dihydrodipicolinate synthase.” Bioorg Med Chem Lett., vol. 18, no. 2, pp. 460–463. Link
  1. V. Mitsakos, R. C. J. Dobson, F. G. Pearce, S. R. Devenish, G. L. Evans, B. R. Burgess, M. A. Perugini, J. A. Gerrard and C. A. Hutton (2008) “Inhibiting dihydrodipicolinate synthase across species: towards specificity for pathogens?” Bioorg Med Chem Lett., vol. 18, no. 2, pp. 842–844. Link
  1. R. C. J. Dobson†, S. C. Atkinson, M. A. Gorman, J. M. Newman, M. W. Parker and M. A. Perugini (2008) “The purification, crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase from Clostridium botulinum.” Acta Crystallogr Sect F Struct Biol Cryst Commun., vol. 64, no. 3, pp. 206–208. Link
    † = Corresponding author
  1. G. Kefala, G. L. Evans, M. D. W. Griffin, S. R. A. Devenish, F. G. Pearce, M. A. Perugini, J. A. Gerrard, M. S. Weiss† and R. C. J. Dobson† (2008) “Crystal structure and kinetic study of dihydrodipicolinate synthase from Mycobacterium tuberculosis.Biochem J., vol. 411, no. 2, pp. 351–10. Link
    † = Corresponding author
  1. S. Androulakis, J. Schmidberger, M. A. Bate, R. DeGori, A. Beitz, C. Keong, B. Cameron, S. McGowan, C. J. Porter, A. Harrison, J. Hunter, J. L. Martin, B. Kobe, R. C. J. Dobson, M. W. Parker, J. C. Whisstock, J. Gray, A. Treloar, D. Groenewegen, N. Dickson and A. M. Buckle (2008) “Federated repositories of X-ray diffraction images.” Acta Crystallogr D Biol Crystallogr., vol. 64, no. 7, pp. 810–814. Link
  1. B. R. Burgess, R. C. J. Dobson†, C. Dogovski, G. B. Jameson, M. W. Parker and M. A. Peruguini† (2008) “Purification, crystallization and preliminary X-ray diffraction studies to near-atomic resolution of dihydrodipicolinate synthase from methicillin-resistant Staphylococcus aureus.” Acta Crystallogr Sect F Struct Biol Cryst Commun., vol. 64, no. 7, pp. 659–661. Link
    † = Corresponding author
  1. M. D. W. Griffin&, R. C. J. Dobson&, F. G. Pearce, L. Antonio, A. E. Whitten, C. K. Liew, J. P. Mackay, J. Trewhella, G. B. Jameson, M. A. Perugini and J. A. Gerrard (2008) “Evolution of quaternary structure in a homotetrameric enzyme.” J Mol Biol., vol. 380, no. 4, pp. 691–703. Link
    & = Joint first author.
  1. B. R. Burgess&, R. C. J. Dobson&, M. F. Bailey, S. C. Atkinson, M. D. W. Griffin, G. B. Jameson, M. W. Parker, J. A. Gerrard and M. A. Perugini (2008) “Structure and evolution of a novel dimeric enzyme from a clinically important bacterial pathogen.” J Biol Chem., vol. 283, no. 41, pp. 27598–27603. Link
    & = Joint first author.
  1. F. G. Pearce, R. C. J. Dobson, A. Weber, L. A. Lane, M. G. McCammon, M. A. Squire, M. A. Perugini, G. B. Jameson, C. V. Robinson and J. A. Gerrard (2008) “Mutating the tight-dimer interface of dihydrodipicolinate synthase disrupts the enzyme quaternary structure: Toward a monomeric enzyme.” Biochemistry, vol. 47, no. 46, pp. 12108–12117. Link
  1. R. C. J. Dobson†, M. D. W. Griffin, S. R. A. Devenish, F. G. Pearce, C. A. Hutton, J. A. Gerrard, G. B. Jameson and M. A. Perugini (2008) “Conserved main-chain peptide distortions: a proposed role for Ile203 in catalysis by dihydrodipicolinate synthase.” Protein Sci., vol. 17, no. 12, pp. 2080–2090. Link
    † = Corresponding author
  1. S. R. A. Devenish, J. A. Gerrard, G. B. Jameson and R. C. J. Dobson (2008) “The high-resolution structure of dihydrodipicolinate synthase from Escherichia coli bound to its first substrate, pyruvate.” Acta Crystallogr Sect F Struct Biol Cryst Commun., vol. 64, no. 12, pp. 1092–1095. Link

2005

  1. J. J. Turner, J. P. Healy, R. C. J. Dobson, J. A. Gerrard and C. A. Hutton (2005) “Two new irreversible inhibitors of dihydrodipicolinate synthase: diethyl (E,E)-4-oxo-2,5-heptadienedioate and diethyl (E)-4-oxo-2-heptenedioate.” Bioorg Med Chem Lett., vol. 15, no. 4, pp. 995–998. Link
  1. R. C. J. Dobson, M. D. W. Griffin, G. B. Jameson and J. A. Gerrard (2005) “The crystal structures of native and (S)-lysine-bound dihydrodipicolinate synthase from Escherichia coli with improved resolution show new features of biological significance.” Acta Crystallogr D Biol Crystallogr., vol. 61, no. 8, pp. 1116–1124. Link
  1. Screen Shot 2015-10-16 at 10.13.20 PMR. C. J. Dobson, S. R. A. Devenish, L. A. Turner, V. R. Clifford, F. G. Pearce, G. B. Jameson and J. A. Gerrard (2005) “Role of arginine 138 in the catalysis and regulation of Escherichia coli dihydrodipicolinate synthase.” Biochemistry, vol. 44, no. 39, pp. 13007–13013. Link

2004

  1. S. J. Roberts, J. C. Morris, R. C. J. Dobson, C. L. Baxter and J. A. Gerrard (2004) “Complete syntheses of (S)-aspartate semi-aldehyde and demonstration that Δ2-tetrahydroisophthalic acid is a non-competitive inhibitor of dihydrodipicolinate synthase.” Arkivoc, vol. x,  pp. 166-177. Link
  1. R. C. J. Dobson, J. A. Gerrard and F. G. Pearce (2004) “Dihydrodipicolinate synthase is not inhibited by its substrate, (S)-aspartate β-semialdehyde.” Biochem J., vol. 377, no. 3, pp. 757–762. Link
  1. R. C. J. Dobson, M. D. W. Griffin, S. J. Roberts and J. A. Gerrard (2004) “Dihydrodipicolinate synthase (DHDPS) from Escherichia coli displays partial mixed inhibition with respect to its first substrate, pyruvate.” Biochimie, vol. 86, no. 4, pp. 311–315. Link
  1. Screen Shot 2015-10-16 at 10.05.33 PMR. C. J. Dobson, K. Valegård and J. A. Gerrard (2004) “The crystal structure of three site-directed mutants of Escherichia coli dihydrodipicolinate synthase: Further evidence for a catalytic triad.” J Mol Biol., vol. 338, no. 2, pp. 329–339. Link

2003

  1. S. J. Roberts, J. C. Morris, R. C. J. Dobson and J. A. Gerrard (2003) “The preparation of (S)-aspartate semi-aldehyde appropriate for use in biochemical studies.” Bioorg Med Chem Lett., vol. 13, no. 2, pp. 265–267. Link

Other published articles

  1. Mandani A, Thompson D., Dobson R, Gieseg S. and Badami K. (2013) Electro-Chemical Changes with ABO-Incompatible Red Blood Cell Transfusions. Gold Coast, Australia: HAA 2013, 20-23 Oct 2013.  (Poster)
  1. Giron, I.O., Dobson, R.C.J. and Hudson, AO. (2011) Characterization of L,L-diaminopimelate aminotransferase from Chlamydomonas reinhardtii. Minneapolis, WI, USA: Plant Biology 2011, 6-10 Aug 2011.
  1. Mills N (2009) Profile of a killer enzyme. Australasian Science March issue (Press artical)
  1. Jones K (2007/8) Protein-protein interactions and enzymology laboratory. What’s New in Lab Technology Vol 18, No. 5, p8. (Press artical)
  1. Hannink N (2008) Cocktail to fix bugs that fight drugs. The Voice Vol 3, No. 9, p6 (Press artical)

Thesis

  1. Dobson, R.C.J. (2004) Investigating the catalytic and regulatory mechanisms of dihydrodipicolinate synthase. PhD, University of Canterbury, Christchurch, New Zealand.