We work on various projects, but our overarching interest is to understand why nature has chosen proteins to mediate life. Proteins are a large family of biopolymers that do (almost) everything in a cell. Just as life is diverse, so too is the biochemical repertoire that proteins must accomplish. We are interested in how they do this. In particular, we look at how the structure and dynamics of a protein leads to its particular function(s) and how these functions are regulated to coordinate cellular metabolism. We are also interested in the evolution of enzyme function, and conversely its design and manipulation. Because the cell is a crowed, complex milieu, comprised of very many different biomolecules, we are also interested in how proteins interact with their environment. A common theme in the lab is the role protein-protein interactions in a variety of biological systems, mostly derived from bacteria, but more recently including eukaryotic proteins involved in cancer, where we hope to address how and why proteins form complexes and the functional consequences of these associations.
We very much appreciate the generous funding from the following sources:
We are always looking for enthusiastic students and staff – if you are interested please contact .